Your brain drives weight gain with Stephan Guyenet, PhD – Diet Doctor Podcast


Could your brain be the most important factor causing weight gain? According to Stephan Guyenet, PhD, yes, it is. Our current foodscape places us in a “genetic-environment mismatch” that promotes weight gain and protects against weight loss. Although it sounds depressing, it doesn’t mean we are without hope.

Stephan and I explore ways to work around our brains’ tendencies in order to succeed with healthy weight loss.

Table of content:
00:00 Introduction
02:10 Welcome, Stephan Guyenet, PhD
08:25 About genetic environmental mismatch
15:50 Energy density and fixing the “hungry brains”
27:45 Lipostat and its implication to weight loss
35:16 Ways to avoid the starvation response
40:48 The intersection of exercise and weight loss
52:12 A mission to prevent the obesity epidemic

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